Antipsychotic Potential of CBD

Here’s something you might not be aware of.

We are all born with an endocannabinoid system and its been hypothesized that a dysfunctional endocannabinoid system could be the reason that people develop psychotic disorders, so it makes sense that CBD holds promise as an interesting antipsychotic option.

Here we’ll take a look at how CBD could function as an antipsychotic, also the research that has led several experts to suggest cannabidiol could be a “potential new type of antipsychotic.”

So let’s delve in and take a deeper look at psychotic disorders themselves.

What are Psychotic Disorders?

Psychotic disorders are some of the most severest mental disorders that cause people to lose touch with reality.

Two of the most heard of and significant symptoms of psychotic disorders include delusions (false beliefs such as thinking someone is out to get you) and hallucinations (seeing, hearing or even feeling something that isn’t actually there).

Schizophrenia is one of the most common psychotic disorders. People that suffer from bipolar disorder may also display symptoms associated with psychosis.

Other factors that may lead to the development of psychosis include heavy drug and/or alcohol use, brain tumors, stroke etc.

According to the World Health Organization (WHO), one in four people will be affected by some type of mental disorder in their life, with schizophrenia affecting more than 21 million people worldwide. That is a quarter of the population. 

It’s also estimated that more than half of those that have schizophrenia are not receiving adequate care.

For those who do receive treatment, it is usually a lifelong commitment…even when symptoms have subsided.

Treatment for Psychosis

Prescription pills are the norm when it comes to treating psychotic disorders, with antipsychotics being the most commonly prescribed medication.

It’s believed they work to manage psychotic symptoms by changing the dopamine levels in the brain.

The problem is that prescription antipsychotics are known for a host of negative side effects.

According to the Mayo Clinic, individuals with schizophrenia are often hesitant to take medications they’re prescribed because of the side effects these prescriptions can cause.

Some of the symptoms associated with antipsychotic medications include:

  • Drowsiness
  •   Dizziness
  • Restlessness
  • Nausea/Vomiting
  • Low blood pressure
  • Blurred vision
  • Seizures
  • Low white blood cell count
  • Persistent muscle spasms
  •   Rigidity
  • Constipation
  • Dry mouth
  • Weight gain
  • Uncontrollable movements (tics and tremors)
  • It’s no wonder people with schizophrenia, bipolar disorder, or other forms of psychosis are hesitant to take these traditional medications for their condition when they experience these side affects.

Here’s something interesting though.

CBD has shown to hold potential as a powerful antipsychotic agent.

Yes it’s true.

Let’s take a look.

CBD: A Potential Antipsychotic

While many people use medical cannabis to alleviate symptoms of depression and anxiety, several studies show that increased consumption of cannabis that contains high levels of THC can actually make it worse, remember I said THC NOT CBD. 

Research indicates, for example, that heavy cannabis use could contribute to developing psychotic disorders.

Here’s the thing, though. This is only with cannabis strains that contain THC.

Interestingly though, CBD seems to have exactly the opposite effect.

In fact, there is evidence that suggests CBD may hold potential as an anti-psychotic treatment. 

And while more research is certainly needed, it presents an exciting opportunity for the portion of the population that suffers from psychosis.

The 2016 review above contends that the chronic use of cannabis strains that contain THC is “a risk factor for the development of schizophrenia,” it also highlights that CBD appears to have zero psychotomimetic potential and that it displays antipsychotic effects in animal models (including both rodents and monkeys).

Schizophrenic animals, however, aren’t the only ones that CBD seems to benefit. There have also been human studies…and the results some show are extremely promising.

How Does CBD Work as an Antipsychotic?

The first randomised, double-blind clinically controlled study found that in patients with schizophrenia, CBD has antipsychotic properties that can be compared to the antipsychotic drug, amisulpride.

The improvement in psychotic symptoms of this particular study was associated with increased levels of anandamide (one of two naturally occurring endocannabinoids in the human body).

And that’s why researchers suggest that the antipsychotic nature of CBD is associated with these increased anandamide concentrations.

Seeing as experts say that a dysfunctional endocannabinoid system seems to contribute to the development of schizophrenia, anandamide is believed to contain protective effects by bringing homeostasis to neurotransmitter imbalance.

It’s suggested that the antipsychotic properties of CBD are exerted by the blocking of FAAH, resulting in an inhibition of anandamide degradation.

It’s also been reported that because CBD binds to gamma receptors that that it could improve glucose metabolism and inflammatory/immune disturbances in schizophrenic patients.

Here’s something else that’s interesting about CBD and schizophrenia.

One of the key negative symptoms of schizophrenia is social withdrawal.

Several studies indicate that CBD has shown to inhibit social withdrawal.

In fact, the majority of studies conducted on animal models report that CBD reduced or reversed induced altered social behavior.

Clinical Studies of CBD for Schizophrenia

The first clinical study of CBD as an antipsychotic took place in 1995. They found that daily administration of up to 1500 mg/day for up to four weeks showed an overall improvement of psychotic symptoms.

The second was small (only with three patients) and took place in 2006. It found that one of the patients displayed an improvement of both negative and positive symptoms.

No side effects were reported by any of the patients.

The third study, we’ve already mentioned, which was the one that found CBD had antipsychotic properties similar to that of the popular antipsychotic drug, amisulpride.

Here’s the thing, though. CBD displayed a far superior side-effect profile when compared to amisulpride. For example, CBD did not cause prolactin increase, weight gain, or extrapyramidal symptoms (restlessness, rigidity, slow movements, irregular jerky movements).

Final Thoughts on CBD as an Antipsychotic

While research into the promise CBD holds as an antipsychotic is at its infancy stage (we need more!), the promise is certainly there.

The evidence is so promising so far that we just read about four more trials currently underway.

The antipsychotic potential of CBD is something that has sparked the interest of several expert researchers and is something that could offer a significantly positive change to the way schizophrenia and other psychotic conditions are treated.

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